1673556-40-5

1673556-40-5 structure

Name: SW203668
Chemical Name: SW203668
CAS Number: 1673556-40-5
Molecular Formula: C₂₂H₁₉N₃O₂S
Molecular Weight: 389.470
Catalog: Research Areas Cancer
Create Date: 2018-06-22 05:32:18
Modify Date: 2025-08-27 11:23:44
SW203668 is a benzothiazole compound, shows anti-tumor activity against lung cancer cell lines (IC50=0.022-0.116 μM)[1].

Name	SW203668
Synonyms	Benzamide, 4-(aminophenylmethyl)-N-(6-methoxy-2-benzothiazolyl)- 4-[Amino(phenyl)methyl]-N-(6-methoxy-1,3-benzothiazol-2-yl)benzamide

Description	SW203668 is a benzothiazole compound, shows anti-tumor activity against lung cancer cell lines (IC50=0.022-0.116 μM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	SW203668 (0.1, 0.3, 1, 3，和 10 μM) 有 2 个苯并噻唑对映体，(+)-SW203668 比 (-)-SW203668 更能与 p37/p30 结合[1]。 SW203668 (1 nM-10 μM; 2 d) 抑制 H2122 细胞生长，IC50 分别为 0.029 μM ((+)-SW203668) 和 0.007 μM ((-)-SW203668)[1]。
In Vivo	SW203668 (25 mg/kg; 腹腔注射; 单次剂量) 在小鼠血浆中半衰期为 8 小时，(6mg /kg, 20mg /kg; 腹腔注射; 每天1次，持续 15 天) 对 CD-1 小鼠低毒[1]。 SW203668 (20 mg/kg; 腹腔注射; 每天 1 次，持续 14 天) 能够保存皮脂细胞，并显著增加小鼠的皮脂细胞数量[1]。 SW203668 (20 mg/kg; 腹腔注射; 每天1次，持续 14 天) 对含有H2122细胞来源的肿瘤异种移植的免疫缺陷型非肥胖糖尿病严重联合免疫缺陷(NOD-SCID)小鼠显示出抗肿瘤效果[1]。
References	[1]. Theodoropoulos PC, et al. Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase. Nat Chem Biol. 2016 Apr;12(4):218-25.