163921-65-1

163921-65-1 structure

163921-65-1 structure

Name: AZITHROMYCIN-D3
Chemical Name: AZITHROMYCIN-D3
CAS Number: 163921-65-1
Molecular Formula: C₃₈H₇₂N₂O₁₂
Molecular Weight: 748.98448
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-10-16 17:50:30
Modify Date: 2024-01-09 11:43:39
Azithromycin-d3 (CP 62993-d3) is the deuterium labeled Azithromycin. Azithromycin (CP-62993) is a macrolide antibiotic useful for the treatment of a number of bacterial infections[1][2].

Name	AZITHROMYCIN-D3

Description	Azithromycin-d3 (CP 62993-d3) is the deuterium labeled Azithromycin. Azithromycin (CP-62993) is a macrolide antibiotic useful for the treatment of a number of bacterial infections[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18. [3]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853.

Melting Point	125-1290C
Molecular Formula	C₃₈H₇₂N₂O₁₂
Molecular Weight	748.98448
Storage condition	-20°C Freezer, Under Inert Atmosphere