145731-49-3

145731-49-3 structure

Name: Z-L-Abu-CONH(CH2)3-morpholine
Chemical Name: CALPAIN INHIBITOR XI
CAS Number: 145731-49-3
Molecular Formula: C₂₆H₄₀N₄O₆
Molecular Weight: 504.6
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2018-06-11 23:30:40
Modify Date: 2025-11-27 09:47:59
Calpain Inhibitor XI is a reversible covalent inhibitor of calpain-1. Calpain Inhibitor XI can be used for the research of neurodegenerative disorders[1].

Name	CALPAIN INHIBITOR XI

Description	Calpain Inhibitor XI is a reversible covalent inhibitor of calpain-1. Calpain Inhibitor XI can be used for the research of neurodegenerative disorders[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Research Areas >> Neurological Disease
In Vitro	Calpain inhibitor XI (CaXI) (1 μM) can inhibit calpain-1, cathepsin-K and also modestly inhibits (∼20%) both papain and cathepsin-B[1].
References	[1]. Rachel C Knopp, et al. Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma. ACS Pharmacol Transl Sci. 2021 Feb 2;4(1):372-385.