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1415800-34-8

1415800-34-8 structure
1415800-34-8 structure
  • Name: Hydroxy-Amino-bis(PEG1-C2-Boc)
  • Chemical Name: Hydroxy-Amino-(PEG2-t-butyl ester)2
  • CAS Number: 1415800-34-8
  • Molecular Formula: C20H39NO7
  • Molecular Weight: 405.526
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-06 09:03:30
  • Modify Date: 2024-01-02 19:57:52
  • Hydroxy-Amino-bis(PEG1-C2-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Hydroxy-Amino-(PEG2-t-butyl ester)2
Synonyms 2-Methyl-2-propanyl 10-(2-hydroxyethyl)-2,2-dimethyl-4-oxo-3,7,13-trioxa-10-azahexadecan-16-oate
3,7,13-Trioxa-10-azahexadecan-16-oic acid, 10-(2-hydroxyethyl)-2,2-dimethyl-4-oxo-, 1,1-dimethylethyl ester
MFCD28657292
Description Hydroxy-Amino-bis(PEG1-C2-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.1±0.1 g/cm3
Boiling Point 478.7±35.0 °C at 760 mmHg
Molecular Formula C20H39NO7
Molecular Weight 405.526
Flash Point 243.3±25.9 °C
Exact Mass 405.272644
LogP 1.02
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.470
Hazard Codes Xi