119670-30-3
119670-30-3 structure
- Name: Z-LVG-CHN2
- Chemical Name: Z-LEU-VAL-GLY-DIAZOMETHYLKETONE
- CAS Number: 119670-30-3
- Molecular Formula: C22H31N5O5
- Molecular Weight: 445.51
- Catalog: Signaling Pathways Anti-infection HSV
- Create Date: 2018-06-07 07:48:51
- Modify Date: 2025-08-20 23:27:55
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Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease[3].
| Name | Z-LEU-VAL-GLY-DIAZOMETHYLKETONE |
|---|---|
| Synonyms | Z-LEU-VAL-GLY-DIAZOMETHYLKETONE |
| Description | Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease[3]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 190 nM (SAR-COV-2)[3] |
| In Vitro | Z-LVG-CHN2 (0-10 μM; pre-treated for 16 h) inhibits antiviral activities in a discernable dose-dependent manner in Vero E6 cells by designed to capture multicycle replication, exhibiting an EC50 value of 0.19 μM[1]/ Cell Viability Assay[3] Cell Line: Vero E6 cells Concentration: 0.001 μM, 0.003 μM, 0.1 μM, 0.3 μM, 1 μM, 2.5 μM Incubation Time: Pre-treated for 16 h and then cultured for 24 hours Result: Inhibited SARS-COV-2 virus replication in a dose-dependent manner. |
| References |
| Molecular Formula | C22H31N5O5 |
|---|---|
| Molecular Weight | 445.51 |
| Storage condition | −20°C |
| Hazard Codes | Xi |
|---|---|
| WGK Germany | 3 |