1095588-70-7

1095588-70-7 structure

Name: 10,11-Dehydrocurvularin
Chemical Name: Dehydrocurvularin, 10,11-
CAS Number: 1095588-70-7
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-07-14 05:59:32
Modify Date: 2024-01-06 16:44:34
10,11-Dehydrocurvularin is an antibiotic and a strong activator of the heat shock response, a conserved evolutionary mechanism that maintains protein homeostasis via the overexpression of heat shock factor 1 (HSF1) and various chaperones including heat shock protein 90 (Hsp90). 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity[1][2].

Name	Dehydrocurvularin, 10,11-

Description	10,11-Dehydrocurvularin is an antibiotic and a strong activator of the heat shock response, a conserved evolutionary mechanism that maintains protein homeostasis via the overexpression of heat shock factor 1 (HSF1) and various chaperones including heat shock protein 90 (Hsp90). 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Heat shock response[1]
References	[1]. Xu Y, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-47. [2]. Cochrane RV, et al. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem. 2015 Nov;16(17):2479-83.

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