1000120-98-8

1000120-98-8 structure

Name: Mipomersen
Chemical Name: mipomersen
CAS Number: 1000120-98-8
Molecular Formula: C₂₃₀H₃₀₅N₆₇O₁₂₂P₁₉S₁₉
Molecular Weight: 7177.00
Catalog: Signaling Pathways Anti-infection HCV
Create Date: 2018-06-21 21:17:23
Modify Date: 2024-01-14 14:30:25
Mipomersen (ISIS 301012 free base) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen can be used for the research of homozygous familial hypercholesterolemia (HoFH)[1][2].

Name	mipomersen
Synonyms	MIPOMERSEN

Description	Mipomersen (ISIS 301012 free base) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen can be used for the research of homozygous familial hypercholesterolemia (HoFH)[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
In Vitro	Mipomersen (800 和 1000 μg/mL；72 小时) 可降低 HCVcc (JFH1) 感染的 Huh7/CD81 WT细胞中 80%-85% 的胞内 HCV RNA[2]。
In Vivo	Mipomersen (25 mg/kg；腹腔注射，每周 2 次，共 11 周) 影响 h-apoB，h-apoB-100，Lp(a) 和 OxPL/h-apoB 的水平[1]。 Animal Model: Transgenic mice overexpressing human apolipoprotein B-100 (h-apoB mice) or h-apoB-100 plus human apo(a) (Lp(a) mice)[1] Dosage: 25 mg/kg Administration: Intraperitoneal injection; 25 mg/kg, twice weekly for 11 weeks Result: Time-dependently reduced the level of h-apoB-100 in Lp(a) mice and h-apoB in h-apoB mice.
References	[1]. Merki E, et al. Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice. Circulation. 2008 Aug 12;118(7):743-53. [2]. Schaefer EA, et al. Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C. World J Gastroenterol. 2016 Dec 7;22(45):9954-9965.

Molecular Formula	C₂₃₀H₃₀₅N₆₇O₁₂₂P₁₉S₁₉
Molecular Weight	7177.00