1346599-65-2

1346599-65-2 structure

Name: Phentolamine-d4 (hydrochloride)
Chemical Name: 3-{[(4,4,5,5-2H4)-4,5-Dihydro-1H-imidazol-2-ylmethyl](4-methylphenyl)amino}phenol hydrochloride (1:1)
CAS Number: 1346599-65-2
Molecular Formula: C₁₇H₁₆D₄ClN₃O
Molecular Weight: 321.838
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-06-25 20:45:27
Modify Date: 2024-01-06 16:33:54
Phentolamine-d4 (Phentolamine-d4) hydrochloride is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction[1][2][3].

Name	3-{[(4,4,5,5-2H4)-4,5-Dihydro-1H-imidazol-2-ylmethyl](4-methylphenyl)amino}phenol hydrochloride (1:1)
Synonyms	Phenol, 3-[[(4,5-dihydro-d2-1H-imidazol-2-yl-4,5-d2)methyl](4-methylphenyl)amino]-, hydrochloride (1:1) 3-{[(4,4,5,5-2H4)-4,5-Dihydro-1H-imidazol-2-ylmethyl](4-methylphenyl)amino}phenol hydrochloride (1:1)

Description	Phentolamine-d4 (Phentolamine-d4) hydrochloride is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Gould L, et, al. Phentolamine. Am Heart J. 1976 Sep;92(3):397-402. [3]. Goldstein I, et, al. Oral phentolamine: an alpha-1, alpha-2 adrenergic antagonist for the treatment of erectile dysfunction. Int J Impot Res. 2000 Mar;12 Suppl 1:S75-80. [4]. Liu L, et, al. Evidence for functional alpha 2D-adrenoceptors in the rat intestine. Br J Pharmacol. 1996 Mar;117(5):787-92. [5]. Pan L, et, al. Phentolamine inhibits angiogenesis in vitro: Suppression of proliferation migration and differentiation of human endothelial cells. Clin Hemorheol Microcirc. 2017;65(1):31-41. [6]. Fioretti AC, et, al. Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and nitric oxide in anesthetized rats. Vascul Pharmacol. 2017 Dec;99:53-64.

Molecular Formula	C₁₇H₁₆D₄ClN₃O
Molecular Weight	321.838
Exact Mass	321.154602

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