283167-06-6
283167-06-6 structure
- Name: FK962
- Chemical Name: N-(1-Acetyl-4-piperidinyl)-4-fluorobenzamide
- CAS Number: 283167-06-6
- Molecular Formula: C14H17FN2O2
- Molecular Weight: 264.295
- Catalog: Research Areas Neurological Disease
- Create Date: 2018-07-18 01:55:01
- Modify Date: 2025-08-25 18:05:14
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FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions[1].
| Name | N-(1-Acetyl-4-piperidinyl)-4-fluorobenzamide |
|---|---|
| Synonyms |
N-(1-Acetyl-4-piperidinyl)-4-fluorobenzamide
N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide Benzamide, N-(1-acetyl-4-piperidinyl)-4-fluoro- MFCD09832545 |
| Description | FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions[1]. |
|---|---|
| Related Catalog | |
| Target |
Somatostatin release[1] |
| In Vitro | FK962 (1 nM-1 μM) significantly enhances high K+-evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp[1]. |
| In Vivo | FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease[2]. Animal Model: Male Lister Hooded rats, weighing approximately 270-300[2] Dosage: 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg Administration: Administered i.p. Result: Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 474.4±40.0 °C at 760 mmHg |
| Molecular Formula | C14H17FN2O2 |
| Molecular Weight | 264.295 |
| Flash Point | 240.7±27.3 °C |
| Exact Mass | 264.127411 |
| LogP | 1.59 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.557 |