1261392-52-2

1261392-52-2 structure

Name: (±)-Naproxen-13C,d3
Chemical Name: 2-{6-[(13C,2H3)Methyloxy]-2-naphthyl}propanoic acid
CAS Number: 1261392-52-2
Molecular Formula: C₁₃₁₃CH₁₁D₃O₃
Molecular Weight: 234.270
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-06-14 04:36:22
Modify Date: 2024-01-28 14:37:23
(±)-Naproxen-13C,d3 is the deuterium and 13C labeled (±)-Naproxen[1]. (±)-Naproxen ((Rac)-Naproxen) is a racemate of Naproxen (HY-15030). Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively.

Name	2-{6-[(13C,2H3)Methyloxy]-2-naphthyl}propanoic acid
Synonyms	2-Naphthaleneacetic acid, α-methyl-6-(methyl-13C-d3-oxy)- 2-{6-[(13C,2H3)Methyloxy]-2-naphthyl}propanoic acid

Description	(±)-Naproxen-13C,d3 is the deuterium and 13C labeled (±)-Naproxen[1]. (±)-Naproxen ((Rac)-Naproxen) is a racemate of Naproxen (HY-15030). Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.