1261113-96-5

1261113-96-5 structure

Name: Ganaplacide
Chemical Name: KAF156
CAS Number: 1261113-96-5
Molecular Formula: C₂₂H₂₃F₂N₅O
Molecular Weight: 411.45
Catalog: Research Areas Infection
Create Date: 2018-06-13 21:09:51
Modify Date: 2025-08-26 17:26:16
Ganaplacide (KAF156) is a first-in-class,orally active imidazolopiperazine antimalarial agent.Ganaplacide is active against a broad range of Plasmodiumspecies, including drug-resistant parasites. Ganaplacide is parasiticidalagainst both asexual and sexual blood stages as well as the liver stages of theparasite[1][2].

Name	KAF156
Synonyms	2-Amino-1-[2-(4-fluorophenyl)-3-[(4-fluorophenyl)amino]-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]ethanone 85VMN9JU7A Ethanone, 2-amino-1-[2-(4-fluorophenyl)-3-[(4-fluorophenyl)amino]-5,6-dihydro-8,8-dimethylimidazo[1,2-a]pyrazin-7(8H)-yl]- KAF156 MFCD28502124

Description	Ganaplacide (KAF156) is a first-in-class,orally active imidazolopiperazine antimalarial agent.Ganaplacide is active against a broad range of Plasmodiumspecies, including drug-resistant parasites. Ganaplacide is parasiticidalagainst both asexual and sexual blood stages as well as the liver stages of theparasite[1][2].
Related Catalog	Research Areas >> Infection
References	[1]. Leong FJ, et al. A first-in-humanrandomized, double-blind, placebo-controlled, single- and multiple-ascendingoral dose study of novel Imidazolopiperazine KAF156 to assess its safety,tolerability, and pharmacokinetics in healthy adult volunteers. AntimicrobAgents Chemother. 2014;58(11):6437-6443. [2]. Kuhen KL, et al. KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrob Agents Chemother. 2014;58(9):5060-5067. [3]. Leong FJ, et al. A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel Imidazolopiperazine KAF156 to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers. Antimicrob Agents Chemother. 2014;58(11):6437-6443.