90458-75-6

90458-75-6 structure

Name: Ecamsule.2Na
Chemical Name: Disodium {1,4-phenylenebis[2-ethyl-1-ylidene(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl-3-ylidene)]}dimethanesulfonate
CAS Number: 90458-75-6
Molecular Formula: C₃₀H₃₆Na₂O₈S₂
Molecular Weight: 634.712
Catalog: Research Areas Others
Create Date: 2018-07-17 09:12:02
Modify Date: 2024-01-09 17:19:13
Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression[1][2].

Name	Disodium {1,4-phenylenebis[2-ethyl-1-ylidene(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl-3-ylidene)]}dimethanesulfonate
Synonyms	Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 3,3'-(1,4-phenylenedi-2-ethyl-1-ylidene)bis[7,7-dimethyl-2-oxo-, sodium salt (1:2) Disodium {1,4-phenylenebis[2-ethyl-1-ylidene(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl-3-ylidene)]}dimethanesulfonate L55 A CVYTJ A1 A1 B1SWQ DU2R D2U- DL55 A CVYTJ A1 A1 B1SWQ &&2Na salt

Description	Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm[1]. Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 μM) treatment. In the fibroblasts, Ecamsule counteractes UV and AAPH induced ROS-formation. In addition, basal ROS levels are reduced. The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 μM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%. Ecamsule increases the viability at the highest applied concentration of 1600 μM in the AAPH-treated cells[1].
References	[1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244. [2]. Vincent A DeLeo, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103.