1007859-25-7

1007859-25-7 structure

Name: Chlorahololide C
Chemical Name: Methyl (2Z)-2-[(1aR,1bS,2R,4bS,8R,8aS,9aS,10aR,10bS,10cS,11aS,11bS)-8-acetoxy-2,11a-dihydroxy-1b,7,10b-trimethyl-9-methylene-3,6-dioxo-1a,1b,2,3,6,8,8a,9,9a,10,10a,10b,10c,11,11a,11b-hexadecahydrocyclopropa[4,5]cyclopropa[4',5']cyclopenta[1',2':7,8]acephenanthryleno[10a,10-b]furan-4(1H)-ylidene]propanoate
CAS Number: 1007859-25-7
Molecular Formula: C₃₃H₃₆O₉
Molecular Weight: 576.633
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2018-06-09 23:16:44
Modify Date: 2024-01-02 08:18:34
Chlorahololide C, a lindenane sesquiterpenoid dimer, is isolated from Chloranthus holostegius. Chlorahololide C is a potent and selective potassium channel blocker, with an IC50 of 3.6 μM[1].

Name	Methyl (2Z)-2-[(1aR,1bS,2R,4bS,8R,8aS,9aS,10aR,10bS,10cS,11aS,11bS)-8-acetoxy-2,11a-dihydroxy-1b,7,10b-trimethyl-9-methylene-3,6-dioxo-1a,1b,2,3,6,8,8a,9,9a,10,10a,10b,10c,11,11a,11b-hexadecahydrocyclopropa[4,5]cyclopropa[4',5']cyclopenta[1',2':7,8]acephenanthryleno[10a,10-b]furan-4(1H)-ylidene]propanoate
Synonyms	Methyl (2Z)-2-[(1aR,1bS,2R,4bS,8R,8aS,9aS,10aR,10bS,10cS,11aS,11bS)-8-acetoxy-2,11a-dihydroxy-1b,7,10b-trimethyl-9-methylene-3,6-dioxo-1a,1b,2,3,6,8,8a,9,9a,10,10a,10b,10c,11,11a,11b-hexadecahydrocyclopropa[4,5]cyclopropa[4',5']cyclopenta[1',2':7,8]acephenanthryleno[10a,10-b]furan-4(1H)-ylidene]propanoate Propanoic acid, 2-[(1aR,1bS,2R,4bS,8R,8aS,9aS,10aR,10bS,10cS,11aS,11bS)-8-(acetyloxy)-1a,1b,2,3,6,8,8a,9,9a,10,10a,10b,10c,11,11a,11b-hexadecahydro-2,11a-dihydroxy-1b,7,10b-trimethyl-9-methylene-3,6-dioxocyclopropa[4,5]cyclopropa[4',5']cyclopent[1',2':7,8]acephenanthryleno[10a,10-b]furan-4(1H)-ylidene]-, methyl ester, (2Z)-

Description	Chlorahololide C, a lindenane sesquiterpenoid dimer, is isolated from Chloranthus holostegius. Chlorahololide C is a potent and selective potassium channel blocker, with an IC50 of 3.6 μM[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 3.6 μM (Chloranthus holostegius)[1]
In Vitro	Chlorahololide C (0.1-100 μM) inhibits the delayed rectifier K+ current (IK) in rat dissociated hippocampal neurons, with an IC50 of 3.6 μM[1].
References	[1]. Yang SP, et, al. Chlorahololides C-F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius. Tetrahedron. 2008 Feb; 64(9):2027-2034.