672945-84-5

672945-84-5 structure

Name: Kansuinine E
Chemical Name: (1aR,3S,4S,5S,7R,7aR,8S,9S,10aR,12R,12aS)-5,7,8,10a-Tetraacetoxy-4-(benzoyloxy)-2,2,9,12-tetramethyl-6-methylene-11-oxotetradecahydro-1aH-cyclopenta[5,6]cyclododeca[1,2-b]oxiren-3-yl nicotinate
CAS Number: 672945-84-5
Molecular Formula: C₄₁H₄₇NO₁₄
Molecular Weight: 777.810
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-06-03 08:07:00
Modify Date: 2025-08-20 18:32:34
Kansuinine E is a plant-derived nitric oxide inhibitor (IC50=6.3 μM). Kansuinine E belongs to jatrophane-type diterpenoids and is isolated from the roots of E. kansui[1].

Name	(1aR,3S,4S,5S,7R,7aR,8S,9S,10aR,12R,12aS)-5,7,8,10a-Tetraacetoxy-4-(benzoyloxy)-2,2,9,12-tetramethyl-6-methylene-11-oxotetradecahydro-1aH-cyclopenta[5,6]cyclododeca[1,2-b]oxiren-3-yl nicotinate
Synonyms	3-Pyridinecarboxylic acid, (1aR,3S,4S,5S,7R,7aR,8S,9S,10aR,12R,12aS)-5,7,8,10a-tetrakis(acetyloxy)-4-(benzoyloxy)tetradecahydro-2,2,9,12-tetramethyl-6-methylene-11-oxo-2H-cyclopenta[5,6]cyclododec[1,2-b]oxiren-3-yl ester (1aR,3S,4S,5S,7R,7aR,8S,9S,10aR,12R,12aS)-5,7,8,10a-Tetraacetoxy-4-(benzoyloxy)-2,2,9,12-tetramethyl-6-methylene-11-oxotetradecahydro-1aH-cyclopenta[5,6]cyclododeca[1,2-b]oxiren-3-yl nicotinate

Description	Kansuinine E is a plant-derived nitric oxide inhibitor (IC50=6.3 μM). Kansuinine E belongs to jatrophane-type diterpenoids and is isolated from the roots of E. kansui[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 6.3 μM (nitric oxide)[1].
References	[1]. Lee JW, et al. Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells. Bioorg Med Chem Lett. 2016;26(14):3351-3354.