328548-11-4
328548-11-4 structure
- Name: OBP-801
- Chemical Name: 30Q3VS5HZ4
- CAS Number: 328548-11-4
- Molecular Formula: C20H31N3O6S2
- Molecular Weight: 473.607
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
- Create Date: 2018-07-08 17:03:53
- Modify Date: 2025-08-24 19:46:57
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Spiruchostatin A is a potent HDAC inhibitor with an IC50 value of 2 nM. Spiruchostatin A can induce apoptosis, has antitumor activity and may be used in leukemia studies[1][2].
| Name | 30Q3VS5HZ4 |
|---|---|
| Synonyms |
(1S,5S,6R,9S,15E,20R)-5-Hydroxy-6-isopropyl-20-methyl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetrone
2-Oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetrone, 5-hydroxy-20-methyl-6-(1-methylethyl)-, (1S,5S,6R,9S,15E,20R)- 30Q3VS5HZ4 OBP-801 |
| Description | Spiruchostatin A is a potent HDAC inhibitor with an IC50 value of 2 nM. Spiruchostatin A can induce apoptosis, has antitumor activity and may be used in leukemia studies[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Spiruchostatin A (3-100 nM, 12 or 24 h) can induce apoptosis in a dose-dependent manner in U937 cells and induce apoptosis in human myelomonocytic lymphoma cell in a time- and dose-dependent manner[1]. Spiruchostatin A (30 nM, 0-24 h) increases in the acetylated histone H3 and H4 levels in a time-dependent manner[1]. Apoptosis Analysis[1] Cell Line: U937 cells, human myelomonocytic lymphoma cells Concentration: 3-100 nM Incubation Time: 12 or 24 h Result: Significantly increased in intracellular reactive oxygen species (ROS) formation. Induced caspase activation and increased the cleaved form of caspase-3 at 30 nM. Induced cytochrome-c release from mitochondria to cytosol at 30 nM. Cell Cycle Analysis[1] Cell Line: U937 cells Concentration: 30 nM Incubation Time: 24 h Result: Increased the percentage of sub-G1 cells from 2.3% to 27%. |
| In Vivo | Spiruchostatin A (YM753) (i.v., 3 mg/kg, once) significantly inhibits tumor growth via accumulation of acetylated histones and p21WAF1/Cip1 protein in the WiDr xenograft model[2]. Animal Model: WiDr xenograft nude mice model bearing tumors[2] Dosage: 3 mg/kg Administration: A single intravenous administration Result: Increased acetylation of histones H3 and H4 even after 72 hours of administration. Showed that YM753 is a prodrug that is reduced to RedYM in tumor cells. Plasma concentrations of YM753 were 558 nM at 3 min and 15 nM at 15 min, in addition, plasma levels of RedYM were 65 nM at 3 min and 1.3 nM at 15 min. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 865.5±65.0 °C at 760 mmHg |
| Molecular Formula | C20H31N3O6S2 |
| Molecular Weight | 473.607 |
| Flash Point | 477.3±34.3 °C |
| Exact Mass | 473.165436 |
| LogP | -0.62 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.516 |