1316189-13-5
1316189-13-5 structure
- Name: m-PEG8-CH2CH2-NHS ester
- Chemical Name: 1-[(29-Oxo-2,5,8,11,14,17,20,23,26-nonaoxanonacosan-29-yl)oxy]-2,5-pyrrolidinedione
- CAS Number: 1316189-13-5
- Molecular Formula: C24H43NO13
- Molecular Weight: 553.597
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-06-02 11:14:30
- Modify Date: 2024-01-17 17:54:45
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m-PEG8-CH2CH2-NHS ester is a PEG--based PROTAC linker can be used in the synthesis of PROTACs.
| Name | 1-[(29-Oxo-2,5,8,11,14,17,20,23,26-nonaoxanonacosan-29-yl)oxy]-2,5-pyrrolidinedione |
|---|---|
| Synonyms |
2,5-Pyrrolidinedione, 1-[(1-oxo-4,7,10,13,16,19,22,25,28-nonaoxanonacos-1-yl)oxy]-
1-[(29-Oxo-2,5,8,11,14,17,20,23,26-nonaoxanonacosan-29-yl)oxy]-2,5-pyrrolidinedione |
| Description | m-PEG8-CH2CH2-NHS ester is a PEG--based PROTAC linker can be used in the synthesis of PROTACs. |
|---|---|
| Related Catalog | |
| Target |
PEGs Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
[1]. Alexander Chucholowski, et al. Cyclodextrin conjugates. WO2010017328A2. [2]. Satwik Kamtekar, et al. Modified biotin-binding proteins for immobilization. WO2019126734A1. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 598.3±60.0 °C at 760 mmHg |
| Molecular Formula | C24H43NO13 |
| Molecular Weight | 553.597 |
| Flash Point | 315.7±32.9 °C |
| Exact Mass | 553.273438 |
| LogP | -4.66 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.489 |
| Hazard Codes | Xi |
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