155178-13-5
155178-13-5 structure
- Name: Amyloid 17-42
- Chemical Name: (4S)-5-[[(1S)-2-[[(1S)-1-[[2-[[(1S)-2-[[(1S)-3-amino-1-[[(1S)-5-amino-1-[[2-[[(1S)-2-[[(1S,2S)-1-[[(1S,2S)-1-[[2-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[2-[[2-[[(1S)-1-[[(1S)-1-[[(1S,2S)-1-[[(1S)-1-carboxyethyl]carbamoyl]-2-methyl-butyl]carbamoyl]-2-methyl-propyl]carbamoyl]-2-methyl-propyl]amino]-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-methylsulfanyl-propyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]carbamoyl]-2-methyl-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]-3-oxo-propyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]amino]-1-(carboxymethyl)-2-oxo-ethyl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methyl-pentanoyl]amino]-3-methyl-butanoyl]amino]-3-phenyl-propanoyl]amino]-3-phenyl-propanoyl]amino]propanoyl]amino]-5-oxo-pentanoic acid
- CAS Number: 155178-13-5
- Molecular Formula: C119H194N28O33S
- Molecular Weight:
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-07-05 02:13:30
- Modify Date: 2024-01-14 09:17:05
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Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal Apoptosis via a Fas-like/caspase-8 activation pathway[1].
| Name | (4S)-5-[[(1S)-2-[[(1S)-1-[[2-[[(1S)-2-[[(1S)-3-amino-1-[[(1S)-5-amino-1-[[2-[[(1S)-2-[[(1S,2S)-1-[[(1S,2S)-1-[[2-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[2-[[2-[[(1S)-1-[[(1S)-1-[[(1S,2S)-1-[[(1S)-1-carboxyethyl]carbamoyl]-2-methyl-butyl]carbamoyl]-2-methyl-propyl]carbamoyl]-2-methyl-propyl]amino]-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-methylsulfanyl-propyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]carbamoyl]-2-methyl-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]-3-oxo-propyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]amino]-1-(carboxymethyl)-2-oxo-ethyl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methyl-pentanoyl]amino]-3-methyl-butanoyl]amino]-3-phenyl-propanoyl]amino]-3-phenyl-propanoyl]amino]propanoyl]amino]-5-oxo-pentanoic acid |
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| Description | Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal Apoptosis via a Fas-like/caspase-8 activation pathway[1]. |
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| Related Catalog | |
| In Vitro | Amyloid 17-42 (20 μM; 48 h) leads to apoptosis in SH-SY5Y and IMR-32 cells[1]. Amyloid 17-42 (20 μM; 48 h, 72 h) activates caspase-8 and caspase-3, induced poly(ADP-ribose) polymerase cleavage[1]. Amyloid 17-42 (20 μM) moderately activates c-Jun N-terminal kinase (JNK)[1]. Amyloid 17-42 induces neuronal apoptosis via a Fas-like/caspase-8 activation pathway[1]. Cell Cytotoxicity Assay[1] Cell Line: SH-SY5Y and IMR-32 cells Concentration: 0-30 μM Incubation Time: 48 h Result: Caused the death of SH-SY5Y and IMR-32 human neuroblastoma cells. Apoptosis Analysis[1] Cell Line: SH-SY5Y cells Concentration: 20 μM Incubation Time: 48 h Result: Showed shrunken cell bodies, condensed and fragmented chromatin, and increased amounts of cytoplasmic oligonucleosomes. Western Blot Analysis[1] Cell Line: SH-SY5Y cells Concentration: 20 μM Incubation Time: 48, 72 h; 18 h, 24 h Result: Reduced procaspase-3 and increased cleaved caspase-3 in cells. Reduced procaspase-8 in cells. Lead to early activation of JNK. |
| References |
| Molecular Formula | C119H194N28O33S |
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