1334782-79-4
1334782-79-4 structure
- Name: PF 05190457
- Chemical Name: FF33NL9U5G
- CAS Number: 1334782-79-4
- Molecular Formula: C29H32N6OS
- Molecular Weight: 512.669
- Catalog: Signaling Pathways GPCR/G Protein GHSR
- Create Date: 2018-07-08 06:28:14
- Modify Date: 2024-01-02 13:22:19
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PF-5190457 is a potent and selective ghrelin receptor inverse agonist with a pKi of 8.36.
| Name | FF33NL9U5G |
|---|---|
| Synonyms |
2-(2-Methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-{2-[(1R)-5-(6-methyl-4-pyrimidinyl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}ethanone
PF-05190457 FF33NL9U5G Ethanone, 1-[2-[(1R)-2,3-dihydro-5-(6-methyl-4-pyrimidinyl)-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)- |
| Description | PF-5190457 is a potent and selective ghrelin receptor inverse agonist with a pKi of 8.36. |
|---|---|
| Related Catalog | |
| Target |
pKi: 8.36 (Humnan ghrelin receptor)[1] |
| In Vitro | PF-5190457 has a superior balance of ghrelin receptor pharmacology and off-target selectivity[1]. |
| In Vivo | PF-5190457 has excellent selectivity and demonstrates robust increases in glucose-stimulated insulin secretion in human whole and dispersed islets[1]. |
| Cell Assay | Human whole islets are incubated in assay buffer containing 2.8 mM glucose for 45 minutes at 37 °C to stabilize insulin secretion; islets are then treated with 11.2 mM glucose in the presence and absence of PF-5190457 for one hour at 37 °C. Following incubation, samples are tested for the amount of insulin secreted into the media[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C29H32N6OS |
| Molecular Weight | 512.669 |
| Exact Mass | 512.235840 |
| LogP | 4.80 |
| Index of Refraction | 1.757 |
| RIDADR | NONH for all modes of transport |
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