170847-18-4

170847-18-4 structure

Name: (RS)-APICA
Chemical Name: 1-Amino-5-phosphono-1-indanecarboxylic acid
CAS Number: 170847-18-4
Molecular Formula: C₁₀H₁₂NO₅P
Molecular Weight: 257.18
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2018-07-21 14:01:44
Modify Date: 2024-02-01 13:28:47
APICA is a potent CB1 and CB2 receptors agonist with EC50 values of 118 nM and 37 nM against CB1 and CB2 receptors, respectively. APICA possess cannabimimetic activity in vivo[1].

Name	1-Amino-5-phosphono-1-indanecarboxylic acid
Synonyms	1-Amino-5-phosphono-1-indanecarboxylic acid 1H-Indene-1-carboxylic acid, 1-amino-2,3-dihydro-5-phosphono- 1-Amino-5-phosphonoindane-1-carboxylic acid

Description	APICA is a potent CB1 and CB2 receptors agonist with EC50 values of 118 nM and 37 nM against CB1 and CB2 receptors, respectively. APICA possess cannabimimetic activity in vivo[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	hCB2-R:37 nM (EC50) hCB1-R:118 nM (EC50)
References	[1]. Longworth M, et al. Synthesis and Pharmacological Profiling of the Metabolites of Synthetic Cannabinoid Drugs APICA, STS-135, ADB-PINACA, and 5F-ADB-PINACA. ACS Chem Neurosci. 2017 Aug 16;8(8):1673-1680.