154303-05-6

154303-05-6 structure

Name: Echistatin
Chemical Name: Echistatin, α1 isoforM
CAS Number: 154303-05-6
Molecular Formula: C₂₁₇H₃₄₁N₇₁O₇₄S₉
Molecular Weight: 5417.0
Catalog: Signaling Pathways Cytoskeleton Integrin
Create Date: 2018-07-07 08:56:36
Modify Date: 2025-08-20 23:49:22
Echistatin, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4].

Name	Echistatin, α1 isoforM

Description	Echistatin, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> Cytoskeleton >> Integrin
Target	αvβ3 α5β1 αIIbβ3
References	[1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73. [2]. M Sato, et al. Echistatin is a potent inhibitor of bone resorption in culture. J Cell Biol. 1990 Oct;111(4):1713-23. [3]. C C Kumar, et al. Biochemical characterization of the binding of echistatin to integrin alphavbeta3 receptor. J Pharmacol Exp Ther. 1997 Nov;283(2):843-53. [4]. I Wierzbicka-Patynowski, et al. Structural requirements of echistatin for the recognition of alpha(v)beta(3) and alpha(5)beta(1) integrins. J Biol Chem. 1999 Dec 31;274(53):37809-14.

Molecular Formula	C₂₁₇H₃₄₁N₇₁O₇₄S₉
Molecular Weight	5417.0

Hazard Codes	Xi
RIDADR	NONH for all modes of transport