Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PYRIDOXAL-5'-PHOSPHATE-6-(2'-NAPHTHYLAZO-6'-NITRO-4',8'-DISULFONATE) TETRASODIUM SALT
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1021868-77-8

1021868-77-8 structure

Name: PPNDS
Chemical Name: Tetrasodium 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonatooxy)methyl]-2-pyridinyl}diazenyl]-7-nitro-1,5-naphthalenedisulfonate
CAS Number: 1021868-77-8
Molecular Formula: C₁₈H₁₁N₄Na₄O₁₄PS₂
Molecular Weight: 694.361
Catalog: Signaling Pathways Membrane Transporter/Ion Channel P2X Receptor
Create Date: 2018-06-25 10:58:54
Modify Date: 2024-01-03 14:24:42
PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP receptor of Paramecium. PPNDS tetrasodium potently inhibits polymerases from viruses. PPNDS tetrasodium can be used in the research of infection and cancers[1][3][4].

Name	Tetrasodium 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonatooxy)methyl]-2-pyridinyl}diazenyl]-7-nitro-1,5-naphthalenedisulfonate
Synonyms	1,5-Naphthalenedisulfonic acid, 3-[(E)-2-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-7-nitro-, sodium salt (1:4) Tetrasodium 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonatooxy)methyl]-2-pyridinyl}diazenyl]-7-nitro-1,5-naphthalenedisulfonate

Description	PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP receptor of Paramecium. PPNDS tetrasodium potently inhibits polymerases from viruses. PPNDS tetrasodium can be used in the research of infection and cancers[1][3][4].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor
Target	ADAM10:1.2 μM (IC50) p2x1 Receptor
In Vitro	PPNDS tetrasodium inhibits meprin β (IC50: 80 nM) and meprin α (67 μM)[1]. PPNDS tetrasodium (0-10 μM, 15 min) inhibits mNV-RdRp (murine Norovirus RNA-dependent RNA-polymerase) with an IC50 value of 0.88 μM[2]. PPNDS tetrasodium (0.025-10 µM) potently inhibits polymerases from six viruses spanning the three Caliciviridae genera tested (IC50 range: 0.1-2.3 μM)[4].
References	[1]. Franck Madoux, et al. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β. Biopolymers. 2014 Sep;102(5):396-406. [2]. Romina Croci, et al. PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases. FEBS Lett. 2014 May 2;588(9):1720-5. [3]. Christopher R Wood, et al. PPNDS is an agonist, not an antagonist, for the ATP receptor of Paramecium. J Exp Biol. 2003 Feb;206(Pt 3):627-36. [4]. Natalie E Netzler, et al. Broad-spectrum non-nucleoside inhibitors for caliciviruses. Antiviral Res. 2017 Oct;146:65-75.

Molecular Formula	C₁₈H₁₁N₄Na₄O₁₄PS₂
Molecular Weight	694.361
Exact Mass	693.904175

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