92510-91-3
92510-91-3 structure
- Name: F 16915
- Chemical Name: F 16915
- CAS Number: 92510-91-3
- Molecular Formula: C28H37NO2
- Molecular Weight: 419.60
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-02-05 06:18:24
- Modify Date: 2024-02-06 18:56:44
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F 16915 is a docosahexaenoic acid derivative which can prevent heart failure-induced atrial fibrillation.
| Name | F 16915 |
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| Description | F 16915 is a docosahexaenoic acid derivative which can prevent heart failure-induced atrial fibrillation. |
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| Related Catalog | |
| In Vivo | F 16915 is a docosahexaenoic acid derivative which can prevent heart failure-induced atrial fibrillation. Time-dependent changes in blood concentrations of total docosahexaenoic acid (DHA) and nicotinyl alcohol are followed after a single oral administration of F 16915 (300 mg/kg) to male rats. Treatment with F 16915 has no significant effect on body weight: 27.7±2.9 kg and 28.1±1.0 kg before surgery versus 29.2±3.4 kg and 28.8±1.7 kg after in the 1 and 5 g/day groups, respectively. F 16915 administered at 5 g/day for 4 weeks significantly reduces the mean duration of Atrial fibrillation (AF) induced by burst pacing but has no significant effect at 1 g/day. The duration of AF is significantly reduced from 989±111 s in the placebo group to 79±59 s in the presence of F 16915 at 5 g/day. Treatment of 2 months with 100 mg/kg F 16915 also significantly reduces the infarct size[1]. |
| Animal Admin | Male Sprague-Dawley rats weighing 220 to 300 g are used in this study. The rats are anesthetized using isoflurane 3% on O2. Then, the animals are intubated and ventilated at 60 respirations/min (2.5 mL/respiration) while anesthesia is maintained. A left thoracotomy is performed, and a silk suture is placed around the left coronary artery ~1 mm from its origin. The treatment starts just after the surgery. A single administration of 100 mg/kg F 16915 or vehicle (olive oil) is daily administrated orally by force-feeding[1]. |
| References |
| Molecular Formula | C28H37NO2 |
|---|---|
| Molecular Weight | 419.60 |
| Storage condition | 2-8℃ |