593274-97-6

593274-97-6 structure

Name: Integrin Antagonists 27
Chemical Name: Integrin Antagonists 27
CAS Number: 593274-97-6
Molecular Formula: C₂₄H₂₀N₄O₅
Molecular Weight: 444.44
Catalog: Signaling Pathways Cytoskeleton Integrin
Create Date: 2018-06-23 06:54:29
Modify Date: 2025-08-24 23:54:55
Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent. Target: Integrinin vitro: Integrin Antagonists 27 is treated with a panel of cancer cell-lines (breast cancer cell line MDA-MB-435, breast cancer cell lines MCF-7, mouse fibroblast NIH3T3, ovarian cancer cell line HEY, lung cancer cell line NCI-H1975) with all IC50 of >20 uM.

Name	Integrin Antagonists 27

Description	Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent. Target: Integrinin vitro: Integrin Antagonists 27 is treated with a panel of cancer cell-lines (breast cancer cell line MDA-MB-435, breast cancer cell lines MCF-7, mouse fibroblast NIH3T3, ovarian cancer cell line HEY, lung cancer cell line NCI-H1975) with all IC50 of >20 uM.
Related Catalog	Signaling Pathways >> Cytoskeleton >> Integrin Research Areas >> Cancer
References	[1]. Dayam R, et al. Discovery of small molecule integrin alphavbeta3 antagonists as novel anticancer agents. J Med Chem. 2006 Jul 27;49(15):4526-4534.