169474-77-5

169474-77-5 structure

Name: FCE 28654
Chemical Name: FCE 28654
CAS Number: 169474-77-5
Molecular Formula: C₂₅H₃₅N₂O₇P
Molecular Weight: 506.53
Catalog: Signaling Pathways Metabolic Enzyme/Protease Acyltransferase
Create Date: 2018-02-20 14:34:12
Modify Date: 2024-01-10 10:52:48
FCE 28654 is a water soluble inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively.

Name	FCE 28654

Description	FCE 28654 is a water soluble inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase Research Areas >> Cardiovascular Disease
Target	IC50: 2.55 μM (ACAT, Rabbit aorta), 1.08 μM (ACAT, Rabbit intestine), 5.69 μM (ACAT, Monkey liver)[1]
In Vitro	FCE 28654 is an inhibitor of ACAT, weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively[1].
In Vivo	FCE 28654 (15 mg/kg, p.o.) dramatically decreases blood cholesterol and modifies the hepatic cholesterol pattern via enhancing the free/esterified cholesterol ratio, in hypercholesterolemic rats. FCE 28654 (100 mg/kg, p.o.) also reduces microsomal ACAT activity rat plasma[1].
References	[1]. A.Chiari, et al. Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor. Bioorganic & Medicinal Chemistry Letters. 1995 Aug 3;5(15):1581-1586.

Molecular Formula	C₂₅H₃₅N₂O₇P
Molecular Weight	506.53