136564-67-5

136564-67-5 structure

136564-67-5 structure

Name: LTD4 antagonist 1
Chemical Name: LTD4 antagonist 1
CAS Number: 136564-67-5
Molecular Formula: C₃₁H₃₂F₃N₃O₅S
Molecular Weight: 615.66
Catalog: Signaling Pathways GPCR/G Protein Leukotriene Receptor
Create Date: 2018-01-18 10:41:48
Modify Date: 2024-01-03 13:13:06
LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM.

Name	LTD4 antagonist 1

Description	LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
Target	LTD4:0.57 nM (Ki)
In Vitro	LTD4 antagonist 1 (Compound 38b) exhibits a Ki of 0.57 nM for displacement of [3H]LTD4 on guinea pig lung membranes, a pKB of 9.93±0.14 versus LTE4 on guinea pig trachea[1].
In Vivo	LTD4 antagonist 1 (Compound 38b) exhibits a po ED50/iv ED50 of 1.44 and 0.036 μmol/kg in LTD4-induced bronchoconstriction in guinea pigs[1].
References	[1]. Robert T. Jacobs, et al. Synthesis, Structure-Activity Relationships, and Pharmacological Evaluation of a Series of Fluorinated 3-Benzyl-5-Indolecarboxamides: Identification of 4-[[5-[((2R)-2-Methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methylindol-3-yl]methyl]-3methoxy-N-[(2-methylphenyl)sulfonyl]benzamide, a Potent, Orally Active Antagonist of Leukotrienes D4 and E4. Journal of Medicinal Chemistry (1994), 37(9), 1282-97.

Molecular Formula	C₃₁H₃₂F₃N₃O₅S
Molecular Weight	615.66