844882-93-5

844882-93-5 structure

Name: IFN alpha-IFNAR-IN-1
Chemical Name: IFN alpha-IFNAR-IN-1
CAS Number: 844882-93-5
Molecular Formula: C₁₈H₁₇NS
Molecular Weight: 279.399
Catalog: Signaling Pathways Immunology/Inflammation IFNAR
Create Date: 2018-03-15 18:46:29
Modify Date: 2024-01-06 19:13:23
IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).IC50 value:Target: IFN alpha-IFNAR interaction inhibitorIFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α [1].

Name	IFN alpha-IFNAR-IN-1
Synonyms	N-Methyl-1-[2-(1-naphthylsulfanyl)phenyl]methanamine Benzenemethanamine, N-methyl-2-(1-naphthalenylthio)-

Description	IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).IC50 value:Target: IFN alpha-IFNAR interaction inhibitorIFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α [1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> IFNAR Research Areas >> Inflammation/Immunology
References	[1]. Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61.