503837-98-7
503837-98-7 structure
- Name: Sortin1
- Chemical Name: Sortin1
- CAS Number: 503837-98-7
- Molecular Formula: C26H19NO6
- Molecular Weight: 441.432
- Catalog: Research Areas Others
- Create Date: 2018-04-25 05:14:57
- Modify Date: 2025-08-21 17:40:37
-
Sortin1 is a chemical genetic-hit molecule that causes specific mislocalization of plant and yeast-soluble and membrane vacuolar markers.IC50 value:Target: Vacuolar markersin vitro: In Arabidopsis seedlings, application of Sortin1 and -2 led to reversible defects in vacuole biogenesis and root development. Sortin1 was found to redirect the vacuolar destination of plant carboxypeptidase Y and other proteins in Arabidopsis suspension cells and cause these proteins to be secreted. Sortin1 treatment of whole Arabidopsis seedlings also resulted in carboxypeptidase Y secretion, indicating that the drug has a similar mode of action in cells and intact plants [1]. Structure-activity relationship studies conducted in Arabidopsis revealed the structural requirements for Sortin1 bioactivity and demonstrated that overlapping Sortin1 substructures can be used to discriminate between vacuolar-flavonoid accumulations and vacuolar-biogenesis defects [2].
| Name | Sortin1 |
|---|---|
| Synonyms |
4-{5-[3-(Methoxycarbonyl)-2-methyl-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridin-4-yl]-2-furyl}benzoic acid
MFCD02217969 1H-Indeno[1,2-b]pyridine-3-carboxylic acid, 4-[5-(4-carboxyphenyl)-2-furanyl]-4,5-dihydro-2-methyl-5-oxo-, 3-methyl ester |
| Description | Sortin1 is a chemical genetic-hit molecule that causes specific mislocalization of plant and yeast-soluble and membrane vacuolar markers.IC50 value:Target: Vacuolar markersin vitro: In Arabidopsis seedlings, application of Sortin1 and -2 led to reversible defects in vacuole biogenesis and root development. Sortin1 was found to redirect the vacuolar destination of plant carboxypeptidase Y and other proteins in Arabidopsis suspension cells and cause these proteins to be secreted. Sortin1 treatment of whole Arabidopsis seedlings also resulted in carboxypeptidase Y secretion, indicating that the drug has a similar mode of action in cells and intact plants [1]. Structure-activity relationship studies conducted in Arabidopsis revealed the structural requirements for Sortin1 bioactivity and demonstrated that overlapping Sortin1 substructures can be used to discriminate between vacuolar-flavonoid accumulations and vacuolar-biogenesis defects [2]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 675.4±55.0 °C at 760 mmHg |
| Molecular Formula | C26H19NO6 |
| Molecular Weight | 441.432 |
| Flash Point | 362.3±31.5 °C |
| Exact Mass | 441.121246 |
| LogP | 4.07 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.696 |
| Storage condition | 2-8℃ |