481658-94-0
481658-94-0 structure
- Name: CP742033
- Chemical Name: CP742033
- CAS Number: 481658-94-0
- Molecular Formula: C40H33F3N4O3
- Molecular Weight: 674.710
- Catalog: Research Areas Metabolic Disease
- Create Date: 2018-01-13 02:31:29
- Modify Date: 2025-08-25 13:05:01
-
CP742033 is a gut-selective inhibitor of microsomal triglyceride transfer protein (MTP) that reliably produces weight loss in obese dogs.
| Name | CP742033 |
|---|---|
| Synonyms |
578H0RMP25
N-((1S)-2-(Benzylmethylamino)-2-oxo-1-phenylethyl)-1-methyl-5-(((4'-(trifluoromethyl)biphenyl-2-yl)carbonyl)amino)-1H-indole-2-carboxamide N-{(1S)-2-[Benzyl(methyl)amino]-2-oxo-1-phenylethyl}-1-methyl-5-({[4'-(trifluoromethyl)-2-biphenylyl]carbonyl}amino)-1H-indole-2-carboxamide N-{(1S)-2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl}-1-methyl-5-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)-1H-indole-2-carboxamide 1H-Indole-2-carboxamide, 1-methyl-N-((1S)-2-(methyl(phenylmethyl)amino)-2-oxo-1-phenylethyl)-5-(((4'-(trifluoromethyl)(1,1'-biphenyl)-2-yl)carbonyl)amino)- Slentrol 1H-Indole-2-carboxamide, 1-methyl-N-[(1S)-2-[methyl(phenylmethyl)amino]-2-oxo-1-phenylethyl]-5-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]- Dirlotapide |
| Description | CP742033 is a gut-selective inhibitor of microsomal triglyceride transfer protein (MTP) that reliably produces weight loss in obese dogs. |
|---|---|
| Related Catalog | |
| In Vivo | Dogs receiving 0.3 mg dirlotapide/kg once daily have a small but significant (P=0.018) decrease (6.16 ± 2.22%, mean ± SD) in crude fat digestibility compared with the placebo-treated food-restricted dogs, but no difference in crude protein, dry matter, or energy digestibility is observed. Dirlotapide effectively reduces appetite and energy intake without affecting nutrient digestibility, except for a minimal decrease in fat digestibility[1]. Dirlotapide (0.5 mg/kg) results in a high rate of weight loss (3.3% weekly) and anorexia, emesis, and loose stools for some dogs. Dirlotapide produces weight loss by both reducing appetite (about 90% of the weight loss activity) and by increasing fecal fat excretion (about 10% of the weight loss activity)[2]. |
| Animal Admin | Dirlotapide in the commercial formulation of a 5-mg/mL oil solution, is administered at an initial rate of 0.5 mg/kg adjusted individually based on the weight loss change in the previous 2 weeks. Dogs assigned to placebo receive the oil vehicle (identical in appearance to the dirlotapide solution) at a rate of 0.1 mL/kg and 0.075 mL/kg during the weight loss and weight management phases, respectively. The dose volume is administered directly into the dog's mouth with a dosing syringe approximately 30 min before feeding. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 821.2±65.0 °C at 760 mmHg |
| Molecular Formula | C40H33F3N4O3 |
| Molecular Weight | 674.710 |
| Flash Point | 450.5±34.3 °C |
| Exact Mass | 674.250488 |
| LogP | 6.95 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.614 |