220460-92-4

220460-92-4 structure

Name: WAY-151932
Chemical Name: WAY-151932
CAS Number: 220460-92-4
Molecular Formula: C₂₃H₁₉ClN₄O
Molecular Weight: 402.876
Catalog: Signaling Pathways GPCR/G Protein Vasopressin Receptor
Create Date: 2018-03-25 10:17:30
Modify Date: 2024-01-11 19:08:44
WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay.

Name	WAY-151932
Synonyms	VNA932 [2-Chloro-4-(3-methyl-1H-pyrazol-1-yl)phenyl](5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl)methanone Methanone, [2-chloro-4-(3-methyl-1H-pyrazol-1-yl)phenyl]-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl-

Description	WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor Research Areas >> Metabolic Disease
Target	IC50: 80.3 nM (human-V2 binding), 778 nM (human-V1a binding)[1]
In Vitro	WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV2 receptors in a dose-dependent manner with an EC50 of 0.74±0.07 nM[2].
In Vivo	Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED50=0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile[2].
References	[1]. Molinari AJ, et al. Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5796-800. [2]. Failli AA, et al. Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists. Bioorg Med Chem Lett. 2006 Feb 15;16(4):954-9.