1808011-22-4

1808011-22-4 structure

Name: EPZ031686
Chemical Name: EPZ031686
CAS Number: 1808011-22-4
Molecular Formula: C₂₆H₃₄ClF₃N₄O₄S
Molecular Weight: 591.086
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2018-03-29 10:56:56
Modify Date: 2025-08-21 19:58:56
EPZ031686 is an orally available SMYD3 inhibitor with an IC50 of 3 nM in cell-free assay.

Name	EPZ031686
Synonyms	6-Chloro-2-oxo-N-[(3-endo)-8-({[1-(4,4,4-trifluorobutyl)-4-piperidinyl]methyl}sulfonyl)-8-azabicyclo[3.2.1]oct-3-yl]-5-indolinecarboxamide MFCD30181978 1H-Indole-5-carboxamide, 6-chloro-2,3-dihydro-2-oxo-N-[(3-endo)-8-[[[1-(4,4,4-trifluorobutyl)-4-piperidinyl]methyl]sulfonyl]-8-azabicyclo[3.2.1]oct-3-yl]-

Description	EPZ031686 is an orally available SMYD3 inhibitor with an IC50 of 3 nM in cell-free assay.
Related Catalog	Signaling Pathways >> Epigenetics >> Histone Methyltransferase Research Areas >> Cancer
References	[1]. Mitchell LH et al. Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. ACS Med Chem Lett. 2015 Aug 27;7(2):134-8.