1010073-75-2
1010073-75-2 structure
- Name: CCR1 antagonist 1
- Chemical Name: CCR1 antagonist 1
- CAS Number: 1010073-75-2
- Molecular Formula: C22H22ClN7O2
- Molecular Weight: 451.909
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-05-15 23:08:03
- Modify Date: 2025-08-25 19:42:13
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CCR1 antagonist 1 is an antagonist of CCR1, with anti-inflammatory activity.
| Name | CCR1 antagonist 1 |
|---|---|
| Synonyms |
1-[4-(4-Chloro-3-methoxyphenyl)-1-piperazinyl]-2-[3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]ethanone
Ethanone, 1-[4-(4-chloro-3-methoxyphenyl)-1-piperazinyl]-2-[3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]- 22PQS5K5TY CCX-354 |
| Description | CCR1 antagonist 1 is an antagonist of CCR1, with anti-inflammatory activity. |
|---|---|
| Related Catalog | |
| Target |
CCR1 |
| In Vitro | CCR1 antagonist 1 shows potent activities in the chemotaxis assay, with IC50 < 100 nM[1]. |
| In Vivo | In vivo, CCR1 antagonist 1 has in vivo anti-inflammatory activity and has superior pharmacokinetic properties[1]. |
| References |
[1]. Compounds for the treatment of osteoporosis and cancers. US 20100113472 A1 |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 778.4±60.0 °C at 760 mmHg |
| Molecular Formula | C22H22ClN7O2 |
| Molecular Weight | 451.909 |
| Flash Point | 424.6±32.9 °C |
| Exact Mass | 451.152344 |
| LogP | 1.24 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.724 |