1898283-02-7
1898283-02-7 structure
- Name: LY3200882
- Chemical Name: LY3200882
- CAS Number: 1898283-02-7
- Molecular Formula: C24H29N5O3
- Molecular Weight: 435.52
- Catalog: Signaling Pathways TGF-beta/Smad TGF-β Receptor
- Create Date: 2018-05-21 08:00:00
- Modify Date: 2024-01-31 21:36:42
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LY3200882 is a novel and highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
| Name | LY3200882 |
|---|
| Description | LY3200882 is a novel and highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). |
|---|---|
| Related Catalog | |
| Target |
TGFβRI[1] |
| In Vitro | LY3200882 is a novel, highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells. LY3200882 has shown anti-metastatic activity in vitro in migration assays. In in vitro immune suppression assays, LY3200882 has shown the ability to rescue TGFβ1 suppressed or T regulatory cell suppressed naïve T cell activity and restore proliferation[1]. |
| In Vivo | LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vivo in subcutaneous tumors in a dose dependent fashion. LY3200882 has shown anti-metastatic activity in vivo in an experimental metastasis tumor model (intravenous EMT6-LM2 model of triple negative breast cancer)[1]. |
| References |
| Molecular Formula | C24H29N5O3 |
|---|---|
| Molecular Weight | 435.52 |
| Storage condition | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |