1800340-40-2
1800340-40-2 structure
- Name: BMS-986158
- Chemical Name: BMS-986158
- CAS Number: 1800340-40-2
- Molecular Formula: C30H33N5O2
- Molecular Weight: 495.62
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2018-05-20 08:00:00
- Modify Date: 2024-01-09 12:21:25
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BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins.
| Name | BMS-986158 |
|---|
| Description | BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins. |
|---|---|
| Related Catalog | |
| Target |
BET[1] |
| In Vitro | BMS-986158 is an inhibitor of the bromodomain (BRD) and extra-terminal domain (BET) family of proteins, with potential antineoplastic activity. Upon administration, the BET inhibitor BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth[2]. |
| References |
[1]. von Schaper E. Roche bets on bromodomains. Nat Biotechnol. 2016 Apr;34(4):361-2. |
| Molecular Formula | C30H33N5O2 |
|---|---|
| Molecular Weight | 495.62 |
| Storage condition | 2-8℃ |