1644443-47-9

1644443-47-9 structure

Name: Autophinib
Chemical Name: Autophinib
CAS Number: 1644443-47-9
Molecular Formula: C₁₄H₁₁ClN₆O₃
Molecular Weight: 346.73
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-05-20 08:00:00
Modify Date: 2025-08-27 10:02:30
Autophinib is a potent autophagy inhibitor, which can inhibit autophagy induced by starvation or rapamycin by targeting the lipid kinase VPS34 with IC50s of 90, 40 and 19 nM, respectively.

Name	Autophinib
Synonyms	MFCD31560472

Description	Autophinib is a potent autophagy inhibitor, which can inhibit autophagy induced by starvation or rapamycin by targeting the lipid kinase VPS34 with IC50s of 90, 40 and 19 nM, respectively.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer Research Areas >> Neurological Disease
Target	IC50: 19 nM (VPS34), 40 nM (rapamycin-induced autophagy), 90 nM (starvation-induced autophagy)[1]
References	[1]. Robke L, et al. Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34. Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8153-8157.