1613373-33-3

1613373-33-3 structure

Name: PCO371
Chemical Name: PCO371
CAS Number: 1613373-33-3
Molecular Formula: C₂₉H₃₂F₃N₅O₆S
Molecular Weight: 635.654
Catalog: Research Areas Endocrinology
Create Date: 2018-04-16 18:36:04
Modify Date: 2024-01-13 18:04:24
PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.

Name	PCO371
Synonyms	1-{3,5-Dimethyl-4-[2-({4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl}sulfonyl)ethyl]phenyl}-5,5-dimethyl-2,4-imidazolidinedione 2,4-Imidazolidinedione, 1-[3,5-dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-

Description	PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.
Related Catalog	Signaling Pathways >> Others >> Thyroid Hormone Receptor Research Areas >> Endocrinology
Target	PTHR1[1]
In Vitro	PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor. PCO371 induces cAMP production with an EC50 of 2.4 μM in COS-7 cells expressing hPTHR1, and 2.5 μM in COS-7 cells transfected with hPTHR1-delNT, and also enhances the phospholipase C activity (EC50, 17 μM)[1].
References	[1]. Tamura T, et al. Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism. Nat Commun. 2016 Nov 18;7:13384.