849727-88-4

849727-88-4 structure

Name: (3R)-2,3-Dihydro-5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-4H-1-benzopyran-4-one
Chemical Name: (3R)-5,7-Dihydroxy-3-(4-hydroxybenzyl)-2,3-dihydro-4H-chromen-4-one
CAS Number: 849727-88-4
Molecular Formula: C₁₆H₁₄O₅
Molecular Weight: 286.279
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-07-07 11:47:34
Modify Date: 2024-02-27 16:34:13
(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, a homoisoflavonoid, has antiangiogenic activity against human retinal microvascular endothelial cells[1].

Name	(3R)-5,7-Dihydroxy-3-(4-hydroxybenzyl)-2,3-dihydro-4H-chromen-4-one
Synonyms	(3R)-5,7-Dihydroxy-3-(4-hydroxybenzyl)-2,3-dihydro-4H-chromen-4-one 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-, (3R)-

Description	(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, a homoisoflavonoid, has antiangiogenic activity against human retinal microvascular endothelial cells[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone has an GI50 value of 35.8 µM on proliferation of human retinal microvascular endothelial cells (HRECs)[1]. (R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone (10 µM, 30 µM, and 100 µM; 8 hours) significantly decreases HRECs overall tubule formation and in a dose-dependent manner[1].
References	[1]. Sianne L Schwikkard, et al. Antiangiogenic Activity and Cytotoxicity of Triterpenoids and Homoisoflavonoids from Massonia pustulata and Massonia bifolia. Planta Med. 2018 Jul;84(9-10):638-644.