118812-69-4

118812-69-4 structure

Name: ularitide
Chemical Name: ularitide
CAS Number: 118812-69-4
Molecular Formula: C₁₄₅H₂₃₄N₅₂O₄₄S₃
Molecular Weight: 3505.927
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-03-06 08:00:00
Modify Date: 2024-01-11 16:48:33
Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure[1][2][4][5].

Name	ularitide
Synonyms	ularitide Urodilatin (human)

Description	Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure[1][2][4][5].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	Ularitide increases the amount of cyclic nucleotides and decreases the raise in permeability in HUVEC cells[2]. Ularitide (1 nM-1 μM, 15 min) reverses methacholine-evoked contraction in bovine bronchi[3]. Ularitide (1 μM, 0-300 s) increases cyclic GMP levels in the presence of phosphoramidon in bovine bronchi[3].
In Vivo	Ularitide (10 nmol/kg, s.c., once) increases in urine volume and sodium excretion in arteriovenous (AV) fistula dogs[1]. Animal Model: Female dogs with or without surgically induced chronic aortocaval fistula[1] Dosage: 5 and 10 pmol/kg/min Administration: i.v. infusions for for 75 min, and thereafter at 10 pmol/kg/min for another 75 min. Result: Increased in urine volume and sodium excretion with high-output CHF.