312271-03-7

312271-03-7 structure

Name: M2I-1
Chemical Name: 5-[4-(Diisobutylamino)-3-nitrobenzylidene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
CAS Number: 312271-03-7
Molecular Formula: C₁₉H₂₄N₄O₄S
Molecular Weight: 404.483
Catalog: Research Areas Others
Create Date: 2018-06-29 11:34:04
Modify Date: 2025-08-23 12:29:10
M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. It can also inhibited the Mad2-F-Mbp1 interaction in FP assays.

Name	5-[4-(Diisobutylamino)-3-nitrobenzylidene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
Synonyms	5-[4-(Diisobutylamino)-3-nitrobenzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione 5-[4-(Diisobutylamino)-3-nitrobenzylidene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione M2I-1 Mad2 inhibitor-1

Description	M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. It can also inhibited the Mad2-F-Mbp1 interaction in FP assays.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Johanna Kastl et al. Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint. ACS Chem. Biol., 2015, 10 (7), pp 1661-1666.