1448723-60-1

1448723-60-1 structure

Name: UM729
Chemical Name: Methyl 4-{[3-(1-piperidinyl)propyl]amino}-1H-pyrimido[4,5-b]indole-7-carboxylate
CAS Number: 1448723-60-1
Molecular Formula: C₂₀H₂₅N₅O₂
Molecular Weight: 367.44
Catalog: Biochemical Inhibitor Metabolism AhR regulator
Create Date: 2018-06-20 12:42:44
Modify Date: 2025-08-23 19:54:43
UM729 is a new pyrimidoindole, which has an additive effect with AhR antagonists in preventing differentiation in most AML specimens; collaborates with Ahr suppressors in preventing AML cell differentiation.IC50 value:Target: SR1 and UM729 can be implemented as a standardized supplement in culture media and will pave the way for studies of self-renewal mechanisms and for the identification of new antileukemic drugs through cell-based assays for primary human AML cells.

Name	Methyl 4-{[3-(1-piperidinyl)propyl]amino}-1H-pyrimido[4,5-b]indole-7-carboxylate
Synonyms	9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester Methyl 4-{[3-(1-piperidinyl)propyl]amino}-1H-pyrimido[4,5-b]indole-7-carboxylate UM729

Description	UM729 is a new pyrimidoindole, which has an additive effect with AhR antagonists in preventing differentiation in most AML specimens; collaborates with Ahr suppressors in preventing AML cell differentiation.IC50 value:Target: SR1 and UM729 can be implemented as a standardized supplement in culture media and will pave the way for studies of self-renewal mechanisms and for the identification of new antileukemic drugs through cell-based assays for primary human AML cells.
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References	[1]. Mojumder DK, et al. Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5796-803. [2]. Flattery, Amy M. et al. Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis. Antimicrobial Agents and Chemotherapy (2011), 55(7), 3491-3497.