1234480-46-6
1234480-46-6 structure
- Name: XMD 8-87
- Chemical Name: 2-{[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino}-11-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
- CAS Number: 1234480-46-6
- Molecular Formula: C24H27N7O2
- Molecular Weight: 445.517
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Tyrosinase
- Create Date: 2018-05-30 07:14:48
- Modify Date: 2024-01-09 11:23:09
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XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively.
| Name | 2-{[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino}-11-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
|---|---|
| Synonyms |
6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-
2-{[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino}-11-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one XMD8-87 |
| Description | XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively. |
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| Related Catalog | |
| Target |
IC50: 38 nM (TNK2, D163E mutation), 113 nM (TNK2, R806Q mutation)[1] |
| In Vitro | XMD8-87 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD8-87 has IC50s of 38 nM and 113 nM for the D163E and R806Q mutations. The effects of XMD8-87 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD8-87[1]. |
| Kinase Assay | Kinase targets are tested with biochemical enzymatic kinase assays using the SelectScreen Kinase Profiling Service to determine IC50 values. The compounds (XMD8-87) are assayed at 10 concentrations (3-fold serial dilutions starting from 1 μM) at an ATP concentration equal to the ATP Km[1]. |
| Cell Assay | Cells are treated with the following inhibitors for 72 hours: dasatinib, AIM-100, XMD8-87 and XMD16-5. Cell viability is measured using a methanethiosulfonate (MTS)-based assay and absorbance (490 nm) is read at 1 and 3 hours after adding reagent[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C24H27N7O2 |
| Molecular Weight | 445.517 |
| Exact Mass | 445.222626 |
| LogP | 1.23 |
| Index of Refraction | 1.648 |
| Storage condition | -20℃ |
| Hazard Codes | N |
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