9073-78-3
9073-78-3 structure
- Name: thermolysin fromGeobacillus stearothermophilus
- Chemical Name: Thermolysin
- CAS Number: 9073-78-3
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Infection
- Create Date: 2018-12-30 13:21:39
- Modify Date: 2024-01-02 20:04:13
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Thermolysin is a thermostable neutral metalloproteinase enzyme secreted by the Gram-positive bacteria Bacillus thermoproteolyticus. Thermolysin catalyzes the hydrolysis of peptide bonds containing hydrophobic residues[1].
| Name | Thermolysin |
|---|---|
| Synonyms | MFCD00165549 |
| Description | Thermolysin is a thermostable neutral metalloproteinase enzyme secreted by the Gram-positive bacteria Bacillus thermoproteolyticus. Thermolysin catalyzes the hydrolysis of peptide bonds containing hydrophobic residues[1]. |
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| Related Catalog | |
| In Vitro | Thermolysin (100 μg in 1 mL, 64°C for 4 h, in isolated starch granules) digestion results in the selective removal of a group of low-molecular-mass proteins ranging between 10 and 27 kD[2]. Thermolysin can be used for the hydrolysis of bovine liver sarcoplasmic proteins[3]. |
| In Vivo | Thermolysin (50 mg/kg, p.o., once) lowers systolic blood pressure in SHR rats[4]. Thermolysin is not acutely toxic with an oral LD50 of more than 18000 mg/kg in rats and more than 24000 mg/kg in mice (Acute toxicity studies)[5]. Animal Model: Spontaneously hypertensive rats (SHR) rats[4] Dosage: 50 mg/kg Administration: Oral administration (p.o.), once Result: Lowered systolic blood pressure in SHR rats, with maximal reduction by 22 mm in systolic blood pressure being observed 6 h after administration. |
| Storage condition | 20°C |
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| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H315-H317-H319-H334-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 36/37/38-42/43 |
| Safety Phrases | 22-26-36/37 |
| RIDADR | NONH for all modes of transport |