1309649-57-7

1309649-57-7 structure

Name: Biotin-PEG4-azide
Chemical Name: Biotin-PEG4-Azide
CAS Number: 1309649-57-7
Molecular Formula: C₂₀H₃₆N₆O₆S
Molecular Weight: 488.601
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-11-24 08:36:51
Modify Date: 2024-01-05 21:05:34
Biotin-PEG4-azide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Biotin-PEG4-Azide
Synonyms	N-(14-Azido-3,6,9,12-tetraoxatetradec-1-yl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide MFCD27977501 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(14-azido-3,6,9,12-tetraoxatetradec-1-yl)hexahydro-2-oxo-, (3aS,4S,6aR)-

Description	Biotin-PEG4-azide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.