115088-06-7

115088-06-7 structure

Name: N-Succinimidyl 4-(2-pyridyldithio)butanoate
Chemical Name: 1-{[4-(2-Pyridinyldisulfanyl)butanoyl]oxy}-2,5-pyrrolidinedione
CAS Number: 115088-06-7
Molecular Formula: C₁₃H₁₄N₂O₄S₂
Molecular Weight: 326.391
Catalog: Research Areas Others
Create Date: 2018-02-04 02:01:16
Modify Date: 2024-01-04 17:55:12
SPDB is a small fragment that can linked DM4 conjugates. Conjugated to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used.

Name	1-{[4-(2-Pyridinyldisulfanyl)butanoyl]oxy}-2,5-pyrrolidinedione
Synonyms	1-{[4-(2-Pyridinyldisulfanyl)butanoyl]oxy}-2,5-pyrrolidinedione 2,5-Pyrrolidinedione, 1-[1-oxo-4-(2-pyridinyldithio)butoxy]- SPDB

Description	SPDB is a small fragment that can linked DM4 conjugates. Conjugated to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing. Bioconjug Chem, 2015 Nov 18, 26(11):2261-78.