1346606-39-0

1346606-39-0 structure

Name: Azoxystrobin-d4
Chemical Name: Methyl (2E)-2-{2-[(6-{[2-cyano(2H4)phenyl]oxy}-4-pyrimidinyl)oxy]phenyl}-3-methoxyacrylate
CAS Number: 1346606-39-0
Molecular Formula: C₂₂H₁₃D₄N₃O₅
Molecular Weight: 407.41
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2018-06-25 14:30:16
Modify Date: 2024-01-02 19:14:59
Azoxystrobin-d4 is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

Name	Methyl (2E)-2-{2-[(6-{[2-cyano(2H4)phenyl]oxy}-4-pyrimidinyl)oxy]phenyl}-3-methoxyacrylate
Synonyms	Benzeneacetic acid, 2-[[6-[(6-cyanophenyl-2,3,4,5-d)oxy]-4-pyrimidinyl]oxy]-α-(methoxymethylene)-, methyl ester, (αE)- Methyl (2E)-2-{2-[(6-{[2-cyano(H)phenyl]oxy}-4-pyrimidinyl)oxy]phenyl}-3-methoxyacrylate

Description	Azoxystrobin-d4 is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Enock Mpofu, et al. Azoxystrobin amine: A novel azoxystrobin degradation product from Bacillus licheniformis strain TAB7. Chemosphere. 2021 Jun;273:129663.