70342-29-9

70342-29-9 structure

Name: Methyl Kakuol
Chemical Name: 1-(6-methoxy-1,3-benzodioxol-5-yl)propan-1-one
CAS Number: 70342-29-9
Molecular Formula: C₁₁H₁₂O₄
Molecular Weight: 208.21100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2018-06-20 11:16:41
Modify Date: 2025-08-27 13:11:34
Methyl kakuol shows agonistic activity against TRPA1 with an EC50 of 0.27 µM[1].

Name	1-(6-methoxy-1,3-benzodioxol-5-yl)propan-1-one
Synonyms	1-Propanone,1-(6-methoxy-1,3-benzodioxol-5-yl) Methyl kakuol

Description	Methyl kakuol shows agonistic activity against TRPA1 with an EC50 of 0.27 µM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease
Target	TRPA1
In Vivo	The maximum concentration (Cmax) of Methyl kakuol at a dose of 2 g/kg (containing 1156 µg/kg, 294 µg/kg, 452 µg/kg, 852 µg/kg asarinin, sesamin, methyl kakuol, and amide A, respectively) is 98.2 ng/mL[1].
References	[1]. Takashi Matsumoto, et al. In Vivo Pharmacokinetic Analysis Utilizing Non-Targeted and Targeted Mass Spectrometry and In Vitro Assay against Transient Receptor Potential Channels of Maobushisaishinto and Its Constituent Asiasari Radix. Molecules. 2020 Sep 18;25(18):4283.