862309-06-6

862309-06-6 structure

Name: MK-0249
Chemical Name: 2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-5-(trifluoromethyl)-4(3H)-quinazolinone
CAS Number: 862309-06-6
Molecular Formula: C₂₃H₂₄F₃N₃O₂
Molecular Weight: 431.45100
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2018-05-24 16:18:23
Modify Date: 2025-09-18 00:05:33
MK-0249 is a potent histamine H3 receptor antagonist, with Ki of 1.7 nM for human H3.

Name	2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-5-(trifluoromethyl)-4(3H)-quinazolinone
Synonyms	2-methyl-(3-{4-[3-(1-pyrrolidinyl)propoxy]phenyl}-5-trifluoromethyl-4(3H)-quinazolinone) 2-methyl-3-{4-[3-(1-pyrrolidinyl)propoxy]phenyl}-5-trifluoromethyl-4(3H)-quinazolinone MK-0249

Description	MK-0249 is a potent histamine H3 receptor antagonist, with Ki of 1.7 nM for human H3.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease
Target	Ki: 1.7 nM (Human H3)[1]
References	[1]. Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46.