165754-55-2

165754-55-2 structure

Name: PESTAHIVIN
Chemical Name: hun-7293
CAS Number: 165754-55-2
Molecular Formula: C₅₃H₈₄N₈O₉
Molecular Weight: 977.28200
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-05-12 16:53:57
Modify Date: 2025-08-24 12:26:09
HUN-7293 is a cell adhesion molecule inhibitor. HUN-7293 selectively inhibits the expression of three cell adhesion molecules (VCAM-1, ICAM-1 and E-selectin) (IC50=1-24 nM). HUN-7293 can be used in the study of inflammatory and autoimmune diseases characterized by overexpression of cell adhesion molecules[1].

Name	hun-7293
Synonyms	3-[(2R,5S,8S,11S,14S,17S,20S)-8,11-Diisobutyl-14-(1-methoxy-1H-indol-3-ylmethyl)-7,13,19,20-tetramethyl-5,17-bis-((R)-2-methyl-hexyl)-3,6,9,12,15,18,21-heptaoxo-1-oxa-4,7,10,13,16,19-hexaaza-cyclohenicos-2-yl]-propionitrile

Description	HUN-7293 is a cell adhesion molecule inhibitor. HUN-7293 selectively inhibits the expression of three cell adhesion molecules (VCAM-1, ICAM-1 and E-selectin) (IC50=1-24 nM). HUN-7293 can be used in the study of inflammatory and autoimmune diseases characterized by overexpression of cell adhesion molecules[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	VCAM-1, ICAM-1, E-selectin[1].
References	[1]. Eva Pauwels, et al. Inhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to Target the Protein Translocation Pathway. Int J Mol Sci, 2021, 22(21), 12007.