140694-19-5

140694-19-5 structure

Name: flaccidoside II
Chemical Name: flaccidoside II
CAS Number: 140694-19-5
Molecular Formula: C₅₉H₉₆O₂₅
Molecular Weight: 1205.38
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-05-27 03:15:36
Modify Date: 2024-01-10 17:25:35
Flaccidoside II inhibits proliferation and induces apoptosis in Malignant peripheral nerve sheath tumors (MPNSTs) cell lines. Flaccidoside II ameliorates collagen-induced arthritis in mice. Flaccidoside II is an active triterpenoid saponin constituent from Anemone flaccida rhizome[1][2].

Name	flaccidoside II
Synonyms	3-O-[α-L-rhamnopyranosyl-(1->2)-β-D-xylopyranosyl]oleanolic acid 28-O-[α-L-rhamnopyranosyl-(1->4)-β-D-glucopyranosyl-(1->6)-β-D-glucopyranosyl] ester 3-O-(α-L-rhamnopyranosyl)-(1->2)-(β-D-xylopyranosyl)-oleanolic acid α-L-rhamnopyranosyl-(1->4)-β-D-glucopyranosyl-(1->6)-α-D-glucopyranosyl ester

Description	Flaccidoside II inhibits proliferation and induces apoptosis in Malignant peripheral nerve sheath tumors (MPNSTs) cell lines. Flaccidoside II ameliorates collagen-induced arthritis in mice. Flaccidoside II is an active triterpenoid saponin constituent from Anemone flaccida rhizome[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology
References	[1]. Zhang GB, et al. Corrigendum to "Flaccidoside II ameliorates collagen-induced arthritis in mice" [Eur. J. Pharmacol. 880 (2020) 173155]. Eur J Pharmacol. 2021 Apr 15;897:173963. [2]. Han LT, et al. Triterpenoid saponin flaccidoside II from Anemone flaccida triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors via the MAPK-HO-1 pathway. Onco Targets Ther. 2016 Apr 5;9:1969-79.