96800-41-8
96800-41-8 structure
- Name: DuP 105
- Chemical Name: (S)-N-<<3-<4(S)-(methylsulfinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide
- CAS Number: 96800-41-8
- Molecular Formula: C13H16N2O4S
- Molecular Weight: 296.34200
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2018-01-31 03:27:23
- Modify Date: 2024-02-03 22:15:52
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DuP 105 is an orally active oxazolidinone, a new class of synthetic antimicrobial agent with activity against gram-positive bacteria.
| Name | (S)-N-<<3-<4(S)-(methylsulfinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide |
|---|---|
| Synonyms |
N-[(S)-3-(4-Methanesulfinyl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide
(S,S)-N-[3-[4-(Methylsulfinyl)phenyl]-2-oxo-5-oxazolidinylmethyl]acetamide (S)-N-<<3-<4(R)-(methylsulfinyl)phenyl>2-oxo-5-oxazolidinyl>methyl>acetamide (S)-N-({3-[4(S)-(methylsulfinyl)phenyl]-2-oxo-5-oxazolidinyl}methyl)acetamide DuP 105 |
| Description | DuP 105 is an orally active oxazolidinone, a new class of synthetic antimicrobial agent with activity against gram-positive bacteria. |
|---|---|
| Related Catalog | |
| In Vitro | DuP 105 shows inhibitory activities against staphylococcal isolates and B. fragilis isolates with MIC90s of 4 to 16 μg/mL and 16 μg/mL[1]. DuP 105 MICs for 50% of the 216 gram-positive isolates tested (MIC50s) range from 4.0 to 16 μg/mL[2]. |
| In Vivo | DuP 105 administered by either the oral or the parenteral route is protective against staphylococcal and streptococcal infections in mice with the 50% effective doses of 9 to 23 mg/kg[1]. |
| Animal Admin | The mice are made neutropenic by the intraperitoneal administration of 100 mg of cyclophosphamide per kg on days -5, -3, and 0 (the day of infection). The extent of immunosuppression is assessed by using a standard hematological technique to determine leukocyte counts. In all experiments, the leukocyte count in the cyclophosphamide-treated mice is less than 15% of that in nontreated mice from day 0 through day 7. On day 0, the mice are injected intraperitoneally with a bacterial inoculum suspended in 0.2 mL of saline containing 5% gastric porcine mucin. This inoculum (2×104 CFU) is fivefold that required to kill all the nontreated immunosuppressed mice in 48 h. Graded doses of the test compounds are administered by the subcutaneous or oral route at 1 and 4 h after infection. In parallel with the immunosuppressed mice, groups of nonimmunosuppressed mice are infected, and treated with the antibacterial drugs. The number of survivors on day 7 in each group is used to calculate the ED50 values of the test compounds. |
| References |
| Molecular Formula | C13H16N2O4S |
|---|---|
| Molecular Weight | 296.34200 |
| Exact Mass | 296.08300 |
| PSA | 94.92000 |
| LogP | 2.20690 |
| Storage condition | 2-8℃ |