103614-76-2

103614-76-2 structure

Name: Halichondrin B
Chemical Name: Halichondrin B
CAS Number: 103614-76-2
Molecular Formula: C₆₀H₈₆O₁₉
Molecular Weight: 1111.31000
Catalog: Research Areas Cancer
Create Date: 2018-03-14 05:14:47
Modify Date: 2025-08-25 11:10:29
Halichondrin B is found from the sponge Halichondria okadai. Halichondrin B is a noncompetitive inhibitor of Vinca-alkaloid binding to tubulin (IC50 for tubulin polymerization of 1.2-1.4 μM). Halichondrin B shows anti-tumor activity[1].

Name	Halichondrin B
Synonyms	halichondrin B

Description	Halichondrin B is found from the sponge Halichondria okadai. Halichondrin B is a noncompetitive inhibitor of Vinca-alkaloid binding to tubulin (IC50 for tubulin polymerization of 1.2-1.4 μM). Halichondrin B shows anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Halichondrin B (0.1-10 nM, 16 h) treatment inhibits the growth of L1210 cells[1]. Cell Cytotoxicity Assay[1] Cell Line: L1210 cells Concentration: 0.1-10 nM Incubation Time: 16 hours Result: Inhibited L1210 cell with IC50 value of 0.3 nM.
References	[1]. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. J Biol Chem. 1991 Aug 25;266(24):15882-9.